Skip to main content

Prostate cancer - Symptoms, Diagnosis, and Treatment

What Causes Prostate Cancer?


Though prostate cancer is common cancer in men, medical professionals are unsure about its exact causes. However, after having studied its risk factors, they believe that all cases of prostate cancer are caused by mutations which cause specific oncogenes to be turned on and certain tumour suppressor genes to be turned off. 


Oncogenes are genes which stimulate the growth of individual cells in the human body, including the prostate. Tumour suppressor genes control cellular growth, repair damage to DNA structures in cells, and contribute to strategic and targeted cellular death.


The mutations which cause the oncogenes to be activated and the tumour suppressor genes to be turned off at the wrong times can be either genetic or acquired.


Inherited genetic mutations


Doctors attribute inherited genetic mutations to 10% of all prostate cancer cases. If a male has inherited the following genetic mutations, you are more likely to develop prostate cancer:


● BRCA1 and BRCA2


● CHEK2, ATM, PALB2, RAD51D


● MSH2, MSH6, MLH1, PMS2 and other DNA mismatch repair genes


● RNASEL


● HOXB13


Remember that the mutations, as mentioned above, are just a few of the inherited genetic mutations, which can cause prostate cancer. They are explained in more detail below.


BRCA1 and BRCA2


These are the genes that cause most types of breast cancer. Because they are genes which cause mutations in the tumour suppressor genes which usually fix mutated DNA ensuring that the resulting malformed cells die immediately. The result is uncontrolled growth of the rogue cells that cause the tumours that are a reason for the occurrence of breast cancer (in women) and prostate cancer (in men!)


ChEK2 ATM, PALB2, and RAD51D


These are genes which repair cells. If they mutate, it can lead to prostate cancer.


DNA mismatch repair genes


Their job is to fix gene pairs that don’t line up correctly immediately before a cell is getting ready to divide. 


RNASEL


This is a gene suppressor gene which kills cells the minute they become dysfunctional. If these genes are turned off, abnormal cells can grow into prostate cancer tumours quickly.


HOXB13


This gene develops prostate gland. Mutations in the HOXB13 gene have been attributed to a higher incidence of prostate cancer.


Acquired genetic mutations


These develop in your lifetime - you don’t inherit them from your parents or ancestors. According to the latest research, acquired genetic mutations cause most prostate cancer cases. When genes divide, they copy the DNA of the original cell (mother cell) into the second cell (daughter cell.) If there are mutations in the DNA during meiosis (cell division), they tend to become permanent and accumulate - hence the higher prevalence of prostate cancer.

Labels:
Location: Mumbai, Maharashtra, India

Comments

Post a Comment

Popular posts from this blog

Fundraisers: Why You Should Use Stories, Not Statistics

Fundraisers: Why You Should Use Stories, Not Statistics Like doers creating dams or geese flying in an establishment, storytelling is an instinctive, defining feature of humans. At Ketto , we believe that stories can transform the glove and change a fundraising campaign as well. For this reason, our all-inclusive crowdfunding platform is made to promote telling stories. Humans Prefer Stories Stories are how people connect with their family members, friends, and even unknown individuals. Humans love stories more than they like nearly anything. They can change everything that occurs to them to a narrative. Storytelling Is Nothing But Science! Do you consider storytelling as a sentimentally emotional response to your online crowdfunding campaign? Reading a story on one of the crowdfunding websites in India like Ketto feels good, but it also has some usefulness: It involves more of the brain in activities. It facilitates insights of points created. It aids a better reminder of those poi...
2 comments
Read more

Huge Rise in Crowdfunding Campaigns to Pay For New Cancer Treatments

Rise in Crowdfunding Campaigns to Pay For Cancer Treatments Cancer puts a massive emotional impact on patients. New research discovers the financial expenses are also extremely high that many people are turning to medical crowdfunding to pay their medical expenses and associated costs. According to doctors’ concerns, a huge number of cancer patients raising funds for their cancer treatments found no other substitute instead of using a crowdfunding app like Ketto.  We encourage people to set up a medical crowdfunding campaign for raising money to pay for the medications needed for the treatment. How Medical Crowdfunding Campaigns Help in Cancer Treatments Earlier, it has been found that cancer patients, who are not insured properly, may need to sell their weather or go bankrupted for paying for medical expenses of these treatments.  Crowdfunding for medical treatment has been used for supporting cancer care requirements and these incorporate the financial impact of insurance ...
Post a Comment
Read more

Prostate cancer - Symptoms, Diagnosis, and Treatment

Meaning of prostate cancer There is a small gland in the men’s testicles which is shaped like a walnut. It is known as Prostate Gland. It produces semen which provides nutrients which sperm needs to survive. As with all body organs, it can develop potentially deadly cancer. It is the second most frequently occurring cancer in men in America and the world. Prostate cancer affects millions, and there were approximately 174,650 new cases in America alone in 2019. About 31,620 American men die every year from prostate cancer. Since its prevalence is increasing throughout the world, you should know about prostate cancer, including its causes, symptoms, diagnosis and treatment. This article will cover this and more. You need to read this article by Ketto, especially if you are a man because doing so could help save your life! What is Prostate Cancer? All men have a prostate which tends to be about the size and shape of a walnut in younger men. Prostates tend to enlarge in men as they age, he...
Post a Comment
Read more